Obstructive sleep apnea syndrome: nocturnal intermittent hypoxia and telomerase complex activity

Obstructive sleep apnea syndrome (OSAS) is a common pathology of the respiratory system characterized by upper airway blockage during sleep. The caused intermittent throat collapse and thereby no lung ventilation with preserved efforts. Earlier we demonstrated that telomeres at end chromosomes shorten nocturnal hypoxia fragmentation in OSA patients; elimination triggers contributed to an increase relative telomere length (RTL). search for relationship between telomerase complex activity stages, as well indicators blood oxygen saturation OSA, seems relevant. Aim. To evaluate main components determine its phases level desaturation patients OSA. Methods. group included 32 men (age 51.2 ± 3.1 years) complaints snoring, arrest sleep, increased daytime control consisted 26 matched volunteers without clinical manifestations Patients both groups did not have any exacerbations their chronic conditions baseline. study questionnaires, polysomnography monitoring, analysis RLT PCR, ELISA components, statistical analysis. Results. Differences were revealed functioning TERT, TEP1. A positive saturation, TER1 was found patients. Conclusion. We identified decrease RTL proved